23/09/2026
Could endo drugs help lipedema? I went down the rabbit hole so you don’t have to.
If “lipedema fat is like endo scar tissue” - can they make a drug that not only dissolves endo scars, but melt lipedema tissue too?
Here’s what the NEW research actually says:
Both conditions build the same thing: fibrotic, immune-active tissue with leaky vessels and a lot of M2 macrophages.
The big endo drugs right now are linzagolix / YSELTY, elagolix, relugolix that turn down estrogen but they don’t dissolve old scar tissue. The scar-dissolving drugs are relaxin-2, pirfenidone only researched in animal studies.
Then there’s Lipedema gene AKR1C1 — your internal off-switch for progesterone inside lipedema fat. In some lipedema families that switch works at 50%. So active progesterone hangs around longer and tells the fat to grow and LOCK.
Again theres no simply ‘fix’ because Lipedema is a tissue-level hormone + immune + fibrosis problem.
Comment ENDO and I’ll DM you my breakdown and reference list.
Save this for your next appointment if you’re dealing with endo & Lipedema.
(Educational only, not medical advice. Always talk to your specialist).