ThirdAge Services LLC

ThirdAge Services LLC

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Personal Consultant/Educator to families on issues with the Dementias

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep 11/02/2019

Very interesting research! When you think about it, it makes sense too. Maybe it will lead somewhere.

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep During non–rapid eye movement sleep, low-frequency oscillations in neural activity support memory consolidation and neuronal computation. Sleep is also associated with increased interstitial fluid volume and clearance of metabolic waste products. It is unknown why these processes co-occur and how ...

Allergan shelling out $750M to settle lawsuit over its Namenda 'hard switch' campaign 10/29/2019

Again folks with dementia are fleeced as well...

Allergan shelling out $750M to settle lawsuit over its Namenda 'hard switch' campaign At the price of a $750 million, Allergan has avoided a trial over its effort to force patients onto a newer version of Namenda as the original neared the patent cliff. The drugmaker will pony up to settle allegations that it delayed cheap Namenda generics with its 'hard switch' plan, costing purchas...

10/01/2019

I wonder how much they made before agreeing to this settlement?

Avanir Pharmaceuticals agreed to pay more than $95 million to resolve kickback allegations and charges of "false and misleading marketing" of dextromethorphan-quinidine (Nuedexta) to manage dementia behavior, an unapproved indication, the Justice Department announced.
Just one day later, Avanir reported its phase III trial of deudextromethorphan hydrobromide-quinidine sulfate -- a version of Nuedexta -- failed at treating agitation in Alzheimer's patients.

Alzheimer's Blood Test Shows 94% Accuracy 08/03/2019

When you read the whole article the headline becomes "less true and less meaningful" in day to day detection or screening for Alzheimer's. This is another example of headline Truthiness rather then the whole truth.

Alzheimer's Blood Test Shows 94% Accuracy Mass spectrometry assay and genetic screen predict brain amyloidosis

Medicare's 'Primary Care First' Program Has Its Skeptics 05/30/2019

Hmmm. Still chasing the less hospitalization thing for cost cutting, instead of paying primary care Doctors who take Medicare enough to keep their practices open

Medicare's 'Primary Care First' Program Has Its Skeptics Too much focus on cutting hospitalizations, not enough $$ for docs, critics say

Can We Live Longer but Stay Younger? 05/14/2019

Here’s a really, really excellent article on research on how to create empathy for older adults with disabilities. Everyone will probably love reading it except P.K. Beeville and the folks at the Virtual Dementia Tour. They’ll probably sue the hell out of this research department.

Can We Live Longer but Stay Younger? With greater longevity, the quest to avoid the infirmities of aging is more urgent than ever.

HLE Calculator 05/14/2019

Want to know how many years you'll live from right now? How many of those years you'll be disabled and need care? Here's an interactive calculator from the University of Connecticut Actuarial Research department. Try it! I have 24 year from now and 8 years of disability. What about you? https://lnkd.in/efQNGgU #

HLE Calculator

05/14/2019

This could be a whole new ball game in research on Alzheimers. Researchers found differences in how genes worked in Myelination (the fatty coating on parts of brain cells) . Myelination is also screwed up in MS (multiple sclerosis) in a few research subjects at MIT. Here's a quote from the leader of the study.

" The team also compared differences in gene expression between early-stage and late-stage Alzheimer’s disease. They identified distinct changes in all the major cell types early in the disease process. Genetic signatures related to myelination were affected in most cell types, suggesting a key role in the disease.

“This study provides, in my view, the very first map for going after all of the molecular processes that are altered in Alzheimer’s disease in every single cell type that we can now reliably characterize,” Kellis says. “It opens up a completely new era for understanding Alzheimer’s.”

—by Geri Piazza

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